Oral pharmacokinetic studies in hamsters revealed that the animals tolerated the treatment as no peculiarities in their behavior were observed. The nodes of the stolons are also very short, which creates very dense colonies ideal for preventing weeds from growing up through the plants. Again these uses are variously transmitted down the centuries, until the external applications disappear by the 18th century. : From ethnopharmacology to phytomedical perspective in the treatment of malaria, Israili and Lyoussi 2009; Ramazanov 2005; Rharrabe et al. Translation of አርማጉሳ in English. Noun 1. genus Ajuga ... Ajuga remota benth. The Salernitan herbal repeats Musa and Dioscorides, but with different dosages or length of administration of the remedy. Item Preview remove-circle Share or Embed This Item. It is a small herbaceous plant (5 at 20 cm in height) known locally in Morocco and Algeria as “Chondgoura” or “Chendghoura” (Miara et al., 2013) and in North-eastern Sahara as “Toutoulba” (Kemassi et al., 2014). The hypoglycaemic activity of different doses of aqueous extracts of the aerial parts of Ajuga iva (L.) Schreb. Azucena Gonzalez-Coloma, ... Braulio M. Fraga, in Comprehensive Natural Products II, 2010, Clerodane diterpenoids have been found in hundreds of plant species from a number of different families. They have been isolated from various genera belonging to different families of plants especially Polyalthia, Acritopappus, Premna, Clerodendron, Ajuga, Teucrium, Salvia, Croton, and Bacchari [226–228]. They also protect plants against phytophagous insects either by feeding deterrence or endocrine disruption upon ingestion, which leads to death. It was found that 40 showed a maximum HMGR inhibition of 78.03% at 100 μM in the in vitro experiments. (2.2), spirafolide from Laurus nobilis L. (2.2), tanshinone IIA from Salvia miltiorrhiza Bunge (2.3), asiatic acid from Centella asiatica (L.) Urb. Diterpene 40 reduced expression levels of GLUT4, PPARγ and C/EBPα and also reduced Akt/mTOR phosphorylation thereby strongly inhibited the factors responsible for early differentiation of adipocytes. Studies show decreased bleeding times in an animal model and possible effects on blood platelets (Ogle, 1977; Ogle, 1976). None of these points is listed in the Old English Herbarium. Matkowski & Piotrowska (2006) included Stachys officinalis in their research into the antioxidant activity of several medicinal herbs. These indications are once again passed down in full or in part through the Renaissance writers as far as Culpeper before disappearing. crenata (Hochst. Table 4. This lower activity of compounds with CO compared with CH2OH seems to be fairly common among the diterpenes. ex Aiton (2.1), eremanthine from Laurus nobilis L. (2.2), 15-methoxypinusolidic acid from Biota orientalis (L.) Endl. Rar. Several genera from the Verbenaceae and Lamiaceae families have been identified as rich sources of neoclerodane diterpenoids. 2007). The structural similarity with statin like lovastatin allowed the comparison, and suggested that 40 might act through inhibition of HMGR as statins. Authors: Sharma, Preeti Mohan, Lalit Srivastava, C N: Issue Date: 4-Sep-2004: Citation: Sharma P, Mohan L, Srivastava CN. The volatile oils of eight species of Stachys growing in Greece were tested against six bacteria and five fungi, and Stachys scardica was the most effective, but, as in many studies, no oil inhibited growth of Pseudomonas aeruginosa (Skaltsa et al 2003). This plant belongs to the family of Labiatae or Lamiaceae, its vernacular name in Algeria is “Chendgoura” or “Chendghoura” (Boudjelal et al., 2015; Miara et al., 2013) or “Toutoulba” (Kemassi et al., 2014) as named in North-eastern Sahara. This name is a synonym of Ajuga integrifolia Buch.-Ham.. Conservatoire et Jardin botaniques de la Ville de Genève. The antidiabetic activity was studied by (El-Hilaly and Lyoussi, 2002; El-hilaly et al., 2007; Hamden et al., 2008), who confirm the hypoglycemic effect in streptozotocin and alloxan induced diabetic rats, supporting its traditional use in the treatment of diabetes. Ajuga reptans, commonly called bugleweed, is a dense, rapidly spreading, mat-forming ground cover which features shiny, dark green leaves. In conclusion, we can agree with Tyler that betony has been proposed for virtually any disease conceived of, certainly up to Culpeper's time. A large number of compounds have already been isolated from A. remota, including ergosterol-5,8-endoperoxide (6), ajugarin-I (1), 8-O-acetylharpagide (5) and several phytoecdysteroids. It also has 100 catfish and many other herbs and spices. The Ajuga genus is unique for the great variety of phytoecdysteroids, with a broad spectrum of biological and pharmacological actions. However, their availability is a problem that would need to be addressed prior to potential exploitation (Table 4). The ability of terpenes to go from medicinal plant to being able to counter neuro-inflammation often rests on the inhibition of nuclear factor kappa-light-chain-enhancer of activated B cells (NF–κB) which command the transcription of cyclo-oxygenase-2 (COX-2) and inducible nitric oxide synthetase (iNOS); the enzymatic activity of which results in the production of prostaglandian E2 (PGE2) and nitric oxide (NO). Bulga Kuntze. A. iva is distributed in the North African and South European countries (Israili and Lyoussi, 2009). Ajuga remota in particular is traditionally used as a herbal remedy for fever and infections, and is prescribed for malaria by 66% of the Kenyan herbalists. Tables of 1H and 13C NMR data on a large number of clerodanes are recorded, together with mass spectral data,341 nuclear Overhauser effects, and crystallographic data.342,343, The chlorinated clerodanes tafricanins A (187) and B (188) were isolated from Teucrium africanum (Labiatae), and their structures determined by X-ray methods.344 Tafricanin B is as active as clerodin against Locusta, but tafricanin A is only weakly active. An antidiabetic effect was reported in Algeria by (Bondi et al., 2000; Boudjelal et al., 2015; Chabane et al., 2013), in Morocco (El-Hilaly and Lyoussi, 2002; El-hilaly et al., 2007) and Tunisia (Hamden et al., 2008). The flowers are arranged in false whorls on the stem apexes. A large number of compounds have already been isolated from A. remota, including ergosterol-5,8-endoperoxide (6), ajugarin-I (1), 8-O-acetylharpagide (5) and several phytoecdysteroids. bab.la arrow_drop_down bab.la - Online dictionaries, vocabulary, conjugation, grammar Toggle navigation Pronunciation of Ajuga reptans with 1 audio pronunciation, 2 synonyms, 2 meanings, 3 translations, 1 sentence and more for Ajuga reptans. Definition of አርማጉሳ is Ajuga remota. The hypoglycemic effect of the aerial part of Ajuga iva (L.) Schreb. aqueous extract improves the antioxidant status by reducing lipid peroxidation, oxidative stress and enhancing the antioxidant enzymes activities in plasma, erythrocytes and tissues of diabetic rats (Bouderbala et al., 2008, 2010; Chenni et al., 2007; Taleb-Senouci et al., 2009). The relative configuration was assigned on the basis of the X-ray crystallographic analysis of its acetate derivative. Definition of ajuga remota is አቆራራጭ፣ አርማጉሳ. Oral administration of 0.15 mg/kg exhibited a significant reduction (62.96 ± 7.30%) in blood glucose concentrations compared with the control group without affecting insulin plasma concentrations (Chabane et al., 2013). ex Vatke : Synonym(s) Heterotypic =Ajuga remota Benth. This study aimed at investigating the in vivo antiplasmodial activity of crude extract of the leaves of Ajuga remota together with its safety in mice models. As secondary plant metabolites, phytoecdysteroids stimulate protein synthesis in plants, activate cell mitosis and possibly act as plant growth regulators. Studies have shown antioxidant activity in a range of Stachys species and found a correlation with the concentration of polyphenols (Háznagy-Radnai et al 2006, Matkowski & Piotrowska 2006, Khanavi et al 2009) although Vundać et al (2007) argue that only the scavenging of free radicals is significant. The comparative antifeedant effects of several nonalkaloidal and alkaloidal ryanoids supported the hypothesis of a ryanodol-specific mode of action in insects.64,67 The insect-selective insecticidal and antifeedant effects of ryanodanes hold a promising future for their use as biopesticides. However, several insect species remain unaffected by ecdysteroids present in their food even at high concentrations. Insecticidal diterpenes for the period 2006–08 (in part), E. David Morgan, Ian D. Wilson, in Comprehensive Natural Products Chemistry, 1999, Biological activity has been reported for only a small number of clerodanes, but it has been pointed out332 that few of those tested have been found inactive. Stachys alopecuros was included in the 13 most useful herbs alongside three species of Origanum but the position of Stachys officinalis was not given (Stamatis et al 2003). Web. Ajuga iva (L.) Schreb. 2007). crenata Hochst. The anti-adipogenic potential was validated in human mesenchymal stem cells and murine mesenchymal cell-line C3H10T1/2. Furthermore, compounds from Plocamium cornutum were evaluated for their antiplasmodial activity against the chloroquine-sensitive P. falciparum strain (Figure 1.17). is a synonym of Ajuga integrifolia Buch.-Ham. was confirmed in alloxan (150 mg/kg BW) rat model of diabetes also by (Boudjelal et al., 2015). Finally, there is a range of external uses to which betony has been put. There are only four other chlorine-containing diterpenes known from terrestrial sources. The leaves of Ajuga remota benth have been utilized traditionally for the treatment of patients with diabetes mellitus. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. In vitro pharmacological studies have been conducted on constituents of A. remota of which some of them displayed a concentration-dependent inhibition of chloroquine-sensitive and -resistant Plasmodium falciparum and Mycobacterium tuberculosis. Dense foliage will choke out weeds. In the current review, we summarized A. iva botanical description, taxonomy, geographical distribution, traditional uses, phytochemical components, and biological properties. It presents gardeners with a tough decision in plant selection. (2000) reported the synthesis of enantiomer of clerodane diterpene via a furan photosensitized oxygenation reaction of (+)-hardwickiic acid [245]. (2.4). Translation for 'ajuga' in the free English-Dutch dictionary and many other Dutch translations. The expressed juice of the leaves or the pounded leaves macerated in water eases pains in the ears if inserted lukewarm after being mixed with rose-oil. Not particularly tolerant of foot traffic. Contextual translation of "ajuga" into English. =Ajuga remota var. Table 1.1. (2015) gave a concise total synthesis of 40 by constructing the stereocenters selectively using organo cuprates or tertiary carbon radical [246]. =Ajuga bracteosa var. Its two known isolates ajugarin-1 and ergosterol-5,8-endoperoxide and a new isolate 8-O-acetylharpagide were evaluated for their in vitro antiplasmodial activity. ajuga remota - ትርጉም Toggle navigation አቢሲኒካ መዝገበ ቃላት From the leaves of Cornutia grandifolia were isolated two clerodanes, cornutin A (189) (0.083%) and cornutin B (190) (0.144%).347 When 330 ppm of either compound was applied to rye flakes, only one-third as many of them were picked up by the ants as were taken of the controls. This time Serapio repeats the use as well, as does Miller in the 18th century alongside rheumatism, for which conditions a diet drink of betony, wood sage (the hepatotoxic Teucrium scorodonia) and ground-pine Ajuga chamaepitys was recommended. 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